期刊
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
卷 24, 期 10, 页码 1714-1726出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1386207323999201117113401
关键词
Silver nanoparticles; Terfezia boudieri; cancer; green synthesis; antibacterial; infections agents
资金
- Alliance of Cardiovascular Researchers
- Elsa U. Pardee Foundation
- Department of Veterans Affairs Research Career Scientist award [IK6BX004016]
- U.S. Department of Veterans Affairs, Office of Research and Development-Biomedical Laboratory Research and Development (ORD-BLRD) Service Award [VA-I01BX004220]
Silver nanoparticles synthesized using an aqueous extract of T. boudieri showed significant cytotoxic and bactericidal effects, ranging in size from 20-30nm. The smaller nanoparticles were correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.
Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic. Methods: Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using an aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we investigated their potential as anti-cancer and antibacterial agents. Results: The synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM, and TEM. In addition, their potential to inhibit cancer cell (proliferation and the growth of infectious bacteria were investigated. Conclusion: The size of nanoparticles ranged between 20-30nm. They exerted significant cytotoxicity and bactericidal effects in a concentration and time-dependent manner compared to T. boudieri extract alone. Interestingly, the synthesis of smaller AgNPs was correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据