期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 196, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111354
关键词
Light sensitive nanoparticles; Controlled drug release; Red-light; Singlet oxygen sensitive molecule; Nanoparticle for cancer therapy; PEG-PLA nanoparticles
资金
- CNPq (National Council for Scientific and Technological Development) [205777/2014-7]
- FEDERfunds through the program COMPETE - Programa Operacional Factores de Competitividade
- FCT- Fundacao para a Ciencia e a Tecnologia [UIDB/00285/2020]
- MATIS [CENTRO-01-0145-FEDER-000014]
- European Regional Development Fund (FEDER)through Programa Operacional Regional do Centro (CENTRO2020)
- FCT [REEQ/481/QUI/2006]
- POCI-2010
- FEDER, Portugal
The development of targeted delivery systems can improve the selectivity of cancer drugs. Additionally, a system that promotes the controlled delivery of the drug triggered by an external stimulus in the exact target tissue is highly desirable. Regarding the light stimulus, the NIR window (650-950 nm) is the most suitable due to its higher capacity of penetration in human tissues and less harmful effects on normal cells. In this work, new red-light-responsive nanoparticles for doxorubicin delivery were developed. The nanoparticles were based on cleavable di-block copolymers of poly(ethylene glycol) (PEG) and poly(lactic acid) (PLA) linked by a red-light sensitive segment (1,2-bis(2-hydroxyethylthio)ethylene, BHETE). The PEG-BHETE-PLA copolymers were synthesized under mild conditions and exhibited a narrow polydispersity. The nanoparticles presented a size between 53 and 133 nm, with a doxorubicin loading capacity between 1.2 and 4.4 wt%. Release study of the encapsulated doxorubicin confirms the light-triggered nanoparticle disassembly process. In vitro cytotoxicity tests in MCF7 cell line, for the light-triggered nanoparticles, showed a decrease in cancer cells' viability higher than 25% compared to non-irradiated cells. Due to the promising results obtained with the light-sensitive PEG-BHETE-PLA nanoparticles, these materials have great potential to be used in drug delivery systems for cancer therapy.
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