期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 197, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111372
关键词
Indocyanine green; Nanomicelle; Cancer photothermal therapy; Fluorescence image-guided surgery; PEGylated conjugation
资金
- National Natural Science Foundation of China [81673384]
A novel amphiphilic mPEG-ACA-ICG conjugate was successfully constructed by modifying ICG with a hydrophobic linker ACA and mPEG, showing improved stability and photothermal conversion efficiency. The nanomicelles exhibited great potential for tumor photothermal therapy and fluorescence image-guided surgery.
Clinical extensive application of indocyanine green (ICG) is limited by several drawbacks such as poor bio-environmental stability, aggregate propensity, and rapid elimination from the body, etc. In this study, we construct a novel amphiphilic mPEG-ACA-ICG conjugate by modifying synthetic heptamethine cyanine derivative ICG-COOH with a hydrophobic linker 6-aminocaproic acid (ACA) and amino-terminal poly(ethylene glycol) (mPEG-NH2). The as-prepared mPEG-ACA-ICG conjugate has the ability to self-assemble into micellar aggregates in an aqueous solution with a lower CMC value than mPEG-ICG conjugate without ACA linker. More importantly, compared with free ICG and mPEG-ICG conjugate, mPEG-ACA-ICG nanomicelles exhibited better stability and higher photothermal conversion efficiency upon near-infrared light irradiation due to the intramolecular introduction of a hydrophobic ACA segment. In our in vivo experiment, mPEG-ACA-ICG nanomicelles ensured the formidable effect on tumor photothermal therapy (PTT) and the maximum tumor inhibition rate reached 72.6 %. In addition, real-time determination ability for fluorescence image-guided surgery (FIGS) of mPEG-ACA-ICG nanomicelles was also confirmed on tumor xenograft mice model. Taken together, mPEG-ACA-ICG conjugate may hold great promise for non-invasive cancer theranostics.
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