期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 608, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.125586
关键词
Microparticles; Hydrogels; Microfluidics; Electrohydrodynamics; PEGDA
资金
- Wadhwani Research Centre for Bioengineering - IIT Bombay [10013208]
Microfluidics-based methods combined electrohydrodynamics with photopolymerization to generate PEGDA microparticles and hydrogels. By adjusting outer flow rates, applied voltages, and monomer concentrations, precise control over particle and hydrogel sizes were achieved. The application of electric fields inside a 3D hybrid microfluidic device provided additional advantages in terms of device fabrication, continuous operation without clogging, and uniform size distribution.
Microfluidics-based methods have emerged as promising routes to generation of microparticles and hydrogels due to the precise control they provide. In this work, we use a microfluidic platform to couple electrohydrodynamics with photopolymerization for generation of polyethylene glycol diacrylate (PEGDA) micro particles and hydrogels. We employ a 3D hybrid glass-PDMS (Polydimethylsiloxane) microfluidic device to first generate PEGDA and PEGDA-water monomer droplets in the presence of electric fields and subsequently solidify them into microparticles and hydrogels through UV irradiation. Application of electric fields provides additional control over the size of the generated entities. Through the use of optical imaging, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared (FTIR) spectroscopy, we investigate the effect of the coupling strategy employed here on the size, uniformity, and morphology of the generated entities. We demonstrate that using a combination of varying outer flow rates, applied voltages, and monomer concentrations, one can tune the PEGDA particle and hydrogel sizes ranging over an order of magnitude while maintaining high monodispersity. In addition to expanding the spectrum of operating parameters, the current approach, through the application of electric fields inside a 3D hybrid microfluidic device, has additional advantages over existing techniques in terms of easy device fabrication, continuous operation without clogging, and uniform size distribution.
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