An ultra-sensitive rifampicin electrochemical sensor based on titanium nanoparticles (TiO2) anchored reduced graphene oxide modified glassy carbon electrode

TiO2 nanoparticles anchored on the reduced graphene oxide (rGO) nanocomposites were prepared by hydro thermal method and characterized by the Xray diffraction (XRD) and transmission electron microscopy (TEM). An effective electrochemical sensing platform for the detection of Rifampicin based upon TiO2 nanoparticles anchored graphene oxide sheets modified glassy carbon electrode (TiO2/rGO/GCE) is reported. Moreover, the TiO2/rGO modified glassy carbon electrode showed an excellent selectivity towards the detection of an antituberculosis drug (Rifampicin). The TiO2/rGO/GCE electrochemical sensing platform is found to exhibit linear range from 0.01 - 0.1 nM with a low limit of detection 0.03 mu M. The fabricated TiO2/rGO/GCE sensor is explored high sensitivity, high stable and good reproducible towards the sensing of RIF and has the potential to be utilized as a clinical assay and pharmaceuticals.

Automated summary

The TiO2 nanoparticles anchored graphene oxide sheets were successfully prepared and showed excellent detection performance towards the antituberculosis drug Rifampicin. The TiO2/rGO/GCE electrochemical sensing platform exhibited a wide linear range and a low detection limit, indicating high sensitivity and potential for clinical and pharmaceutical applications.