4.7 Article

Field Performance and Public Health Response Using the BinaxNOW™ Rapid Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigen Detection Assay During Community-Based Testing

期刊

CLINICAL INFECTIOUS DISEASES
卷 73, 期 9, 页码 E3098-E3101

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1890

关键词

community-based SARS-CoV-2 testing; asymptomatic SARS-CoV-2 infection

资金

  1. University of California San Francisco, Program for Breakthrough Biomedical Research - Sandler Foundation
  2. Chan Zuckerberg Initiative
  3. National Institutes of Health [UM1AI069496]

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The study conducted testing for SARS-CoV-2 among 3302 individuals in a community setting using BinaxNOW(TM) and reverse transcription polymerase chain reaction (RT-PCR). The rapid assay showed high sensitivity and specificity, with consistent performance across different age groups and symptomatic status, allowing for immediate public health action.
Among 3302 persons tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by BinaxNOW (TM) and reverse transcription polymerase chain reaction (RT-PCR) in a community setting, rapid assay sensitivity was 100%/98.5%/89% using RT-PCR cycle thresholds of 30, 35, and no threshold. The specificity was 99.9%. Performance was high across ages and those with and without symptoms. Rapid resulting permitted immediate public health action.

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