期刊
CLINICAL INFECTIOUS DISEASES
卷 71, 期 -, 页码 S436-S439出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1521
关键词
Carbapenem-resistant K. pneumoniae; Ceftazidime-avibactam; Meropenem-vaborbactam; bla(KPC-2); bla(KPC-33)
资金
- National Natural Science Foundation of China [81871690, 81902101, 81861138051]
- National Mega-project for Innovative Drugs [2019ZX09721001-006-004]
- China Antimicrobial Surveillance Network [2020QD049]
This is the first report of ceftazidime-avibactam resistance caused by the bla(KPC-33) mutation through the D179Y variant during the treatment of bla(KPC-2)-positive Klebsiella pneumoniae-related infections in China. The bla(KPC-33)-containing K. pneumoniae was susceptible to meropenem-vaborbactam, cefepime-zidebactam, tigecycline, and polymyxin B. The bla(KPC-33) gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and bla(LAP-2). Detecting bla(KPC-33)-positive K. pneumoniae clinical strains is important for infection control.
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