4.4 Article

Skeletal disproportion in girls with Turner syndrome and longitudinal change with growth-promoting therapy

期刊

CLINICAL ENDOCRINOLOGY
卷 94, 期 5, 页码 797-803

出版社

WILEY
DOI: 10.1111/cen.14413

关键词

anthropometry; growth disorders; human growth hormone; longitudinal studies; methods; oestrogens; skeletal disproportion; Turner syndrome

向作者/读者索取更多资源

Short stature in Turner syndrome may be accompanied by skeletal disproportion. Girls with severe short stature are more likely to have skeletal disproportion, but only half of those with milder degrees of short stature. Growth-promoting therapy may improve disproportion during both childhood and pubertal growth phases.
Objective Short stature in Turner syndrome (TS) may be accompanied by skeletal disproportion. This retrospective study investigates growth and disproportion from early childhood to adult height. Study design Data were collected from 59 girls prior to growth hormone (rhGH) treatment and in 30 girls followed up longitudinally. Standard deviation scores (SDS) for height (Ht), sitting height (SH) and sub-ischial leg length (LL) were compared and a disproportion score (SH SDS - LL SDS) calculated. Results In 59 girls, mean (SD) age 6.6 (2.1) years prior to rhGH treatment, LL SDS of -3.4 (1.1) was significantly lower than SH SDS of -1.2 (0.8) [p < .001]. In girls with Ht SDS < -2.0, disproportion score was > +2.0 in 27 (63%), cf eight (50%) with Ht SDS >= -2.0. For the longitudinal analysis, skeletal disproportion prior to rhGH was +2.4 (1.1) and +1.7 (1.0) on rhGH but prior to introduction of oestrogen [p < .001]. Disproportion at adult height was +1.1 (0.8), which was less marked than at the earlier time points [p < .001 for both comparisons]. Change in disproportion SDS over the first two years of rhGH predicted overall change in disproportion from baseline to adult height [R-2 51.7%, p < .001]. Conclusion TS is associated with skeletal disproportion, which is more severe in the shortest girls and present in only half of those with milder degrees of short stature. Growth-promoting therapy may improve disproportion during both the childhood and pubertal phases of growth. Change in disproportion status two years after starting rhGH helps predict disproportion at adult height.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据