Transcription Strikes Back: Clinical Utility of Lung Adenocarcinoma Subtypes

Summary: This study classified lung adenocarcinomas into mutinous, proliferative, and mesenchymal subtypes based on signaling similarities, identifying a lack of discrete and causative mutational etiology in these transcriptional states. The subtypes captured heterogeneity even among tumors lacking known oncogenic drivers, demonstrating subtype stability under selective pressure. Furthermore, heterogeneity among in vitro and in vivo preclinical models was expounded by the human lung adenocarcinoma subtypes, offering potential for the discovery of subtype-specific vulnerabilities.