CASC15 Polymorphisms are Correlated With Breast Cancer Susceptibility in Chinese Han Women

The study was carried out in 1361 participants, involving 681 patients with breast cancer (BC) and 680 unrelated healthy controls from Shaanxi Provincial Cancer Hospital. We performed single-nucleotide polymorphism genotyping using the Agena MassARRAY platform. The relationship between long noncoding RNA cancer susceptibility candidate 15 (CASC15) polymorphism and the risk of BC were estimated through odds ratios and 95% confidence intervals. The results illustrated long noncoding RNAs CASC15 polymorphisms may have an influence on BC susceptibility in Chinese women. Introduction: Breast cancer (BC) is a prevalent malignant tumor among women. Numerous studies have been reported that long noncoding RNAs (lncRNAs) were associated with various human diseases. Materials and Methods: In the current study, 681 patients with BC and 680 unrelated controls were recruited to investigate the correlation between lncRNA cancer susceptibility candidate 15 (CASC15) polymorphisms and BC risk in Chinese Han women. We performed single-nucleotide polymorphism genotyping using the Agena MassARRAY platform. The relationship between lncRNA CASC15 polymorphisms and the risk of BC were evaluated through odds ratios and 95% confidence intervals. Results: Our results suggested that the lncRNA CASC15 rs7740084 G/G genotype and rs1928168 T/C genotype significantly reduced BC risk in different genetic models (P = .045, P 1/4 .029, and P = .047, respectively). However, rs9393266 C/T and C/T-T/T genotypes were correlated with the risk of BC (P = .021 and P = .048). In addition, we also observed that rs1928168 was related to the risk of BC in patients with age > 50 years (P = .025), body mass index > 24 (P = .006), and tumor size (P = .035). For rs9393266, it was revealed that the C/T and C/T-T/ T genotypes were related to BC risk in people with age similar to 50 years (P = .005) and body mass index > 24 (P = .023). Conclusion: In summary, our results revealed a potential interaction between lncRNA CASC15 polymorphisms and BC susceptibility. The results provided an important insight into lncRNA CASC15 function in the development of BC. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

The study explored the relationship between long noncoding RNA CASC15 polymorphisms and the risk of breast cancer in Chinese Han women. The results suggested that certain genotypes of lncRNA CASC15 were associated with reduced or increased risk of breast cancer, providing insight into the development of the disease.