期刊
CHINESE MEDICAL JOURNAL
卷 134, 期 2, 页码 143-150出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000001320
关键词
Cerebral small vessel disease; Clinical spectrum; Pathophysiology
资金
- National Key Research and Development Program of China [2016YFC13600600]
The age-related sporadic cerebral small vessel disease (CSVD) has become increasingly prominent due to the aging population. The advancement in brain magnetic resonance imaging has enhanced researchers' understanding of CSVD. This review provides an update on the pathophysiology, risk factors, biomarkers, and clinical manifestations of sporadic CSVD.
Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.
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