期刊
CHINESE JOURNAL OF CHEMISTRY
卷 39, 期 6, 页码 1690-1705出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202000600
关键词
Catellani reaction; Palladium; Domino reaction; C— H activation; Vicinal functionalization
The Catellani reaction, discovered by Catellani in 1997 and further developed by Catellani, Lautens, and others, is a powerful strategy for the synthesis of polysubstituted arenes. This method allows for the simultaneous functionalization of both ortho- and ipso-positions of aryl halides with different electrophiles and terminating agents under the cooperative catalysis of palladium and norbornene. The review focuses on the significant progress in such transformations and categorizes typical Catellani reactions into five parts based on the functionalization modes of ortho-C-H bonds: alkylation, arylation, amination, acylation, or thiolation.
The Catellani reaction, originally discovered by Catellani in 1997, and further developed by Catellani, Lautens and others, has emerged as a powerful strategy for the synthesis of polysubstituted arenes, which would be difficult to access via traditional methods. In this process, both ortho- and ipso-positions of aryl halides could be functionalized simultaneously with different electrophiles and terminating agents under the cooperative catalysis of palladium and norbornene (NBE). This review focuses on the significant progress of such transformations, and the section of typical Catellani reactions is divided into five parts according to the functionalization mode of ortho-C-H bond: alkylation, arylation, amination, acylation or thiolation.
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