Metal-free direct C(sp3)-H functionalization of 2-alkylthiobenzoic acid to access 1,3-benzooxathiin-4-one

Metal-free direct alpha-C(sp(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor is described. This novel strategy provides a facile and efficient method to access important 1,3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

The metal-free direct alpha-C(sp(3))-H intramolecular cyclization of 2-alkylthiobenzoic acid in the presence of Selectfluor provides a facile and efficient method to access important 1,3-benzooxathiin-4-one derivatives with good functional groups tolerance and yields.