Beyond the Isoprene Pattern: Bifunctional Polyene Cyclizations

Polyene cyclizations are capable of producing molecular complexity in a single step. While classical systems are limited to simple alkyl substitution patterns only, bifunctional polyenes take advantage of the unique reactivity of higher-functionalized alkenes. Here, we highlight the potential of these variants for the synthesis of structurally complex polycycles involving unprecedented termination steps. We also want to provide a stimulus for the development of novel modes of cyclization that involve bifunctional units to enable efficient synthesis of yet inaccessible natural products.

Automated summary

Polyene cyclizations can produce molecular complexity in a single step, bifunctional polyenes utilize the unique reactivity of highly functionalized alkenes, and have the potential to synthesize complex polycycles.