期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 11, 页码 3694-3699出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202005391
关键词
alkynes; dicarbofunctionalization; enynes; palladium; radical coupling
资金
- German Science Foundation
A conceptually distinct approach was developed for the dicarbofunctionalization of alkynes at room temperature using simple alkyl iodides and a second molecule of alkyne as coupling partner. This method enables the one-step synthesis of 1,3-enynes with high efficiency without the need for exogenous photosensitizers or oxidants, paving the way for cascade reactions via photochemical palladium catalysis.
Herein, a conceptually distinct approach was developed that allowed for the dicarbofunctionalization of alkynes at room temperature using simple, bench-stable alkyl iodides and a second molecule of alkyne as coupling partner. Specifically, the photochemical activation of palladium complexes enabled this strategic dicarbofunctionalization via addition of alkyl radicals from secondary and tertiary alkyl iodides and formation of an intermediate palladium vinyl complex that could undergo subsequent Sonogashira reaction with a second alkyne molecule. This alkylation-alkynylation sequence allowed the one-step synthesis of 1,3-enynes including heteroarenes and biologically active compounds with high efficiency without exogenous photosensitizers or oxidants and now opens up pathways towards cascade reactions via photochemical palladium catalysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据