Electroreductive Nickel-Catalyzed Thiolation: Efficient Cross-Electrophile Coupling for C-S Formation

Sulfur-containing molecules are of utmost topical importance towards the effective development of pharmaceuticals and functional materials. Herein, we present an efficient and mild electrochemical thiolation by cross-electrophile coupling of alkyl bromides with functionalized bench-stable thiosulfonates to access alkyl sulfides with excellent efficacy and broad functional group tolerance. Cyclic voltammetry and potentiostatic analysis were performed to elucidate mechanistic insights into this electrocatalytic thiolation reaction.

Automated summary

In this research, an efficient and mild electrochemical thiolation method was developed for the synthesis of alkyl sulfides by cross-electrophile coupling of alkyl bromides with bench-stable thiosulfonates. Mechanistic insights into this electrocatalytic thiolation reaction were elucidated through cyclic voltammetry and potentiostatic analysis.