期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 9, 页码 2987-2992出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202004335
关键词
controlled release; doxorubicin; drug delivery; hyaluronic acid; metal-organic frameworks
资金
- Hebei Provincial Natural Science Foundation of China [B2015202291, B2019202003]
- NNSFC [21402038]
The porous nano-sized metal-organic framework, with proper surface modification, enhances drug loading capability and introduces biocompatibility, biodegradability, and targeting functions in nano-drug delivery systems. The obtained nanoMOF nanoparticle is stable in physiological fluids and can effectively load chemotherapeutic drugs for controlled release in tumor tissues.
The porous nano-sized metal-organic framework (nanoMOF) and its proper surface modification could greatly promote the drug loading capability and introduce biocompatibility, biodegradability, and targeting functions into nano-drug delivery systems. Herein, the HACD@ADA-PA/MIL-101_NH2 (Fe)-P nanoparticle was successfully fabricated through supramolecular and coordination interactions from three building blocks, including hierarchically porous MIL-101_NH2 (Fe)-P nanoMOF, phosphite-modified adamantane (ADA-PA), and beta-cyclodextrin (beta-CD)-modified hyaluronic acid (HACD). The obtained HACD@ADA-PA/MIL-101_NH2 (Fe)-P nanoparticle was nano-sized and highly stable in physiological fluids. The porous structure of HACD@ADA-PA/MIL-101_NH2 (Fe)-P nanoparticle could effectively load the commercial chemotherapeutic drug doxorubicin (DOX) with an encapsulation rate of 41.20 % and a loading rate of 48.84 %. The obtained drug-loaded HACD@ADA-PA/MIL-101_NH2 (Fe)-P@DOX nanoparticle was pH-sensitive and relatively stable at neutral condition (pH 7.2) but could release DOX in a controlled way in subacid solution at pH 5.7. The simulated in vitro DOX release experiment signified that the HACD@ADA-PA/MIL-101_NH2 (Fe)-P@DOX nanoparticle could realize the controlled release of DOX in tumor issues.
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