期刊
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
卷 56, 期 12, 页码 1491-1516出版社
SPRINGER
DOI: 10.1007/s10593-020-02843-w
关键词
pyridine; agrochemicals; bioisosterism; fungicides; herbicides; insecticides; nematicides; plant protection; zoocides
The pyridine scaffold has been described as the most commercially successful heterocycle in the synthesis of plant protection chemicals in the 21st century, with the ability to modify compound properties and serve as a unique pharmacophore. Examples of pyridine intermediates used in the manufacture of agrochemicals are provided, along with explanations of the compounds' mechanisms of action when known.
95 agrochemical products have been described based on the pyridine scaffold making it the most commercially successful heterocycle in the synthesis of plant protection chemicals in the 21st century. The pyridine fragment is capable of modifying the properties of compounds, sometimes changing their application, and can be a unique pharmacophore. When possible, the relationship of pyridine analogs with carbocyclic or aliphatic precursors is shown. The mechanism of action of the compounds is described, if known. Examples of syntheses of pyridine intermediates used in the manufacture of agrochemicals are given.
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