期刊
CHEMISTRY & BIODIVERSITY
卷 18, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000794
关键词
Phyllogonium viride; cytotoxic activity; bryophytes; phytochemistry; moss; essential oil
The study aimed to determine the chemical composition and biological activity of the essential oil from Phyllogonium viride Brid., with major compounds found being beta-bazzanene, beta-caryophyllene, beta-chamigrene, and germacrene B. Treatment with the essential oil did not induce toxicity in most tested cell lines. The data contributes to new scientific information about this plant species and its biotechnological potential.
The present study aimed to determine the chemical composition and biological activity of the essential oil obtained from Phyllogonium viride Brid. (Phyllogoniaceae, Bryophyta), whose samples were collected in southern Brazil. For the first time, the cytotoxic activity of the essential oil of P. viride in breast and colorectal tumor cells (MCF-7 and HCT-116) was evaluated, as well as the cytotoxic potential of this oil in non-tumoral cells of human immortalized keratinocytes (HaCaT) via MTT assay. The compounds majorly found in P. viride essential oil were beta-bazzanene (20.30 %), beta-caryophyllene (17.06 %), beta-chamigrene (14.02), and germacrene B (11.72 %). Treatment with P. viride essential oil in the different tested cell lines did not induce any toxicity in most of the tested concentrations. These data contribute to generating new scientific information about this understudied plant species. Furthermore, the chemical characterization of the compounds present in the essential oil of P. viride can lead to greater elucidation of its biotechnological potential.
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