期刊
CHEMISTRY & BIODIVERSITY
卷 18, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000919
关键词
diterpenoids; euphorfischerins; Euphorbiaceae; Euphorbia fischeriana; cytotoxic activities
资金
- National Natural Science Foundation of China [31300283]
- Natural Science Foundation of Shaanxi Province [2015JM3111]
- Chinese Universities Scientific Fund [Z109021547, 2014YB025]
Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Euphorfischerin A and euphorfischerin B showed cytotoxicity against human cancer cell lines.
Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Their chemical structures and absolute configurations were determined by interpretation of NMR, HR-ESI-MS, ECD and X-ray diffraction data. Euphorfischerin A showed cytotoxicity against the human cancer cell lines HeLa, H460 and Namalwa with IC50 values of 4.6, 11.5 and 16.4 mu M, respectively, while euphorfischerin B gave comparable IC50 values of 9.5, 17.4 and 13.3 mu M against the three cancer cell lines, respectively.
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