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Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry

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CHEMICAL REVIEWS
卷 121, 期 3, 页码 1582-1622

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AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.0c00709

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资金

  1. EPSRC [EP/S035990/1]
  2. GlaxoSmithKline
  3. EPSRC [EP/S035990/1] Funding Source: UKRI

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This review discusses the reasons behind the widespread use of chlorinated solvents in chemistry laboratories, the increasing drive to minimize their usage, and the current alternatives available.
Chlorinated solvents were once, and in many places are still, ubiquitous in chemistry laboratories. This review explores the properties that led to such widespread use, why there is now an increasing drive to minimize usage, and what alternatives are currently available.

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