期刊
CHEMICAL REVIEWS
卷 121, 期 12, 页码 6718-6743出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.0c00806
关键词
-
资金
- French Research National Agency [ANR-19-CE06-0006-01]
Click chemistry and bio-orthogonal reactions are primarily based on cycloaddition reactions, especially 1,3-dipolar cycloadditions. Mesoionic compounds have recently emerged as attractive dipole partners due to their ability to be derivatized and have their reactivity tuned towards cycloaddition reactions. Some compounds from the mesoionic family can also undergo click-and-release reactions, showing interesting applications in cells and animals.
Click and bio-orthogonal reactions are dominated by cycloaddition reactions in general and 1,3-dipolar cycloadditions in particular. Among the dipoles routinely used for click chemistry, azides, nitrones, isonitriles, and nitrile oxides are the most popular. This review is focused on the emerging click chemistry that uses mesoionic compounds as dipole partners. Mesoionics are a very old family of molecules, but their use as reactants for click and bio-orthogonal chemistry is quite recent. The facility to derivatize these dipoles and to tune their reactivity toward cycloaddition reactions makes mesoionics an attractive opportunity for future click chemistry development. In addition, some compounds from this family are able to undergo click-and-release reactions, finding interesting applications in cells, as well as in animals. This review covers the synthetic access to main mesoionics, their reaction with dipolarophiles, and recent applications in chemical biology and heterocycle synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据