期刊
CHEMICAL REVIEWS
卷 121, 期 4, 页码 2413-2444出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.0c00825
关键词
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资金
- Institute of General Medical Sciences of the United States Department of Health and Human Services [R35 GM127097]
- United States National Science Foundation [CHE-1665389]
The HDDA reaction is a thermal cyclization process that generates highly functionalized benzenoid products, attracting attention for its versatility and customizable nature among researchers.
The hexadehydro-Diels-Alder (HDDA) reaction is the thermal cyclization of an alkyne and a 1,3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a variety of species to yield highly functionalized benzenoid products. In contrast to nearly all other methods of aryne generation, no other reagents are required to produce an HDDA benzyne. The versatile and customizable nature of the process has attracted much attention due not only to its synthetic potential but also because of the fundamental mechanistic insights the studies often afford. The authors have attempted to provide here a comprehensive compilation of publications appearing by mid-2020 that describe experimental results of HDDA reactions.
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