期刊
CHEMICAL ENGINEERING JOURNAL
卷 417, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.128278
关键词
Silk fibroin; Self-healing hydrogel; Wound dressing; Photopolymerization; Host-guest interaction
资金
- National Natural Science Foundation of China [51973172, 51673155]
- Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
- State Key Laboratory for Mechanical Behavior of Materials
- Fundamental Research Funds for the Central Universities
- World-Class Universities (Disciplines)
- Characteristic Development Guidance Funds for the Central Universities
- Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2019LHM-KFKT008]
A novel self-healing SF-based hydrogel was developed through dual crosslinking for enhanced wound dressing performance and as a drug carrier with controlled release, showing great potential in wound healing.
Silk fibroin (SF) based hydrogels possess great potential in wound healing. However, they have limitations as wound dressings, such as long-gelation time, high temperature or organic solvent-assisted treatment, and lack of self-healing property. In this study, a supramolecular hydrogel based on SF, acryloyl-beta-cyclodextrin (Ac-CD) and 2-hydroxyethyl acrylate was developed through a facile method by photo-polymerization of acrylate under UV irradiation, and showed enhanced performance as wound dressing than commercial dressing. This SF based hydrogel was confirmed to be dually crosslinked by host-guest interaction and hydrophobic beta-sheet conformation, and demonstrated improved mechanical properties, long-term stability, rapid self-healing behavior, injectability, and good biocompatibility, benefiting its application as wound dressing. Moreover, as a drug carrier owing abundant CDs, the hydrophobic drug curcumin with antioxidant and anti-inflammatory activity was loaded in SF-based hydrogel, accompanying with a controlled and sustained release profile, therewith boosting better wound healing performance with generating higher granulation tissue thickness, collagen disposition, upregulating vascular endothelial growth factor (VEGF), and decreasing inflammatory response in a full-thickness skin defect model. In conclusion, this novel self-healing SF-based hydrogel is of great value in wound healing and enriches the fabrication methodology of SF-based self-healing biomaterials as well.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据