期刊
CHEMICAL ENGINEERING JOURNAL
卷 417, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.128073
关键词
Microfluidics; Droplet; Inverse opal; Patch; Wettability
资金
- National Key Research and Development Program of China [2020YFA0908200]
- National Natural Science Foundation of China [52073060, 61927805]
- Natural Science Foundation of Jiangsu [BE2018707]
- Wenzhou Institute-University of Chinese Academy of Sciences 's startup fund [WIUCASQD2019007, WIUCASQD2020001]
- Emergency Project of Wenzhou [ZY202005]
A novel Janus porous patch with anisotropic surface wettability was created from microfluidic droplet templates for wound healing, demonstrating efficient drainage of exudate and prevention of undesired tissue adhesion in a rat skin defect model. This study offers a promising strategy for the clinical treatment of skin wound diseases.
Biological patches with controllable surface wettability have received extensive attention in fundamental research and clinical practice. Herein, we present a novel Janus porous patch with anisotmpic surface wettability derived from microfluidic droplet templates for wound healing. Such patch was fabricated by magnetic-induced assembly and replicating of hydrophilic and hydrophobic colloidosomes into a double-layered, close-packing film. The resultant film displayed anisotropic surface wettability applicable for efficient drainage of exudate and avoided undesired tissue adhesion. The wound healing performance of the patch film was demonstrated by a rat skin defect model, with antimicrobial peptide incorporated for anti-infection purposes. This study provides novel patch materials with specially controlled surface wettability for wound repair, and offers a promising strategy for clinical treatment of skin wound diseases.
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