期刊
CHEMICAL ENGINEERING & TECHNOLOGY
卷 44, 期 3, 页码 457-464出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ceat.202000475
关键词
In-line filtration; Lipid nanoparticles; Membrane filtration; Nanoparticle synthesis; Precipitation
资金
- Niedersachsisches Ministerium fur Wissenschaft und Kultur (MWK) of the Federal State of Lower Saxony (Germany)
- Boehringer Ingelheim
- MWK of Lower Saxony (Germany) within the SMART BIOTECS alliance
- Projekt DEAL
Microfluidic processes show potential for producing nanoparticles with reproducible properties, but accidental production of larger particles remains a challenge. To address this issue, a class of microfluidic filters has been developed to eliminate particulate contamination in multistage continuous-flow processes, aiming to achieve higher filtration efficiency.
Microfluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental production of larger particles, which can contaminate the product or clog downstream process modules. A class of microfluidic filters was devised for eliminating particulate contamination in multistage continuous-flow processes. To achieve high throughput and filtration efficiency, a high-surface-area filter with an application-adapted bonding method was developed. As a model application, the filtration efficiency was analyzed for lipid nanoparticles made by microfluidic antisolvent precipitation and the results were compared with requirements of the European and US guidelines.
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