4.6 Article

Multi-faceted Set-up of a Diverse Ketoreductase Library Enables the Synthesis of Pharmaceutically-relevant Secondary Alcohols

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

UniProt: a worldwide hub of protein knowledge

Alex Bateman et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Chemistry, Inorganic & Nuclear

Catalytic Homogeneous Asymmetric Hydrogenation: Successes and Opportunities

Chris S. G. Seo et al.

ORGANOMETALLICS (2019)

Review Chemistry, Inorganic & Nuclear

A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

John D. Hayler et al.

ORGANOMETALLICS (2019)

Article Chemistry, Multidisciplinary

Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction

Feng Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Biochemistry & Molecular Biology

Efficient Preparation of (S)-N-Boc-3-Hydroxylpiperidine Through Bioreduction by a Thermostable Aldo-KetoReductase

Mengyan He et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2017)

Article Chemistry, Organic

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib

Chong Han et al.

ORGANIC LETTERS (2017)

Article Biochemistry & Molecular Biology

Probing the influence of non-covalent contact networks identified by charge density analysis on the oxidoreductase BacC

Kumar Perinbam et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2017)

Article Chemistry, Organic

Development of a practical biocatalytic process for (S)-N-Boc-3-hydroxypiperidine synthesis

Li-Feng Chen et al.

TETRAHEDRON LETTERS (2017)

Article Chemistry, Medicinal

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

Matthew D. Truppo

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Physical

Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1

Gao-Wei Zheng et al.

ACS CATALYSIS (2017)

Review Chemistry, Multidisciplinary

A Retrosynthesis Approach for Biocatalysis in Organic Synthesis

Rodrigo O. M. A. de Souza et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

Article Biotechnology & Applied Microbiology

Rapid asymmetric reduction of ethyl 4-chloro-3-oxobutanoate using a thermostabilized mutant of ketoreductase ChKRED20

Feng-Jiao Zhao et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Assessing the stereoselectivity of carbonyl reductases toward the reduction of OPBE and docking analysis

Rong Chen et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Chemoenzymatic synthesis of (S)-duloxetine using carbonyl reductase from Rhodosporidium toruloides

Xiang Chen et al.

BIOORGANIC CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Asymmetric synthesis of lipitor chiral intermediate using a robust carbonyl reductase at high substrate to catalyst ratio

Guo-Chao Xu et al.

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC (2016)

Article Biochemistry & Molecular Biology

Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03

Guang-Peng Xu et al.

PROCESS BIOCHEMISTRY (2016)

Article Multidisciplinary Sciences

Origins of stereoselectivity in evolved ketoreductases

Elizabeth L. Noey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

UniProt: a hub for protein information

Alex Bateman et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Law

China's shifting patent landscape and State-led patenting strategy

Dan Prud'homme

JOURNAL OF INTELLECTUAL PROPERTY LAW & PRACTICE (2015)

Article Chemistry, Applied

Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

Sonia Rodriguez et al.

ADVANCED SYNTHESIS & CATALYSIS (2014)

Article Chemistry, Multidisciplinary

Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase

Shanshan Wang et al.

CHEMICAL COMMUNICATIONS (2014)

Article Biotechnology & Applied Microbiology

Biocatalytic anti-Prelog reduction of prochiral ketones with whole cells of Acetobacter pasteurianus GIM1.158

Peng-Xuan Du et al.

MICROBIAL CELL FACTORIES (2014)

Article Chemistry, Applied

Development of a Biocatalytic Process to Prepare (S)-N-Boc-3-hydroxypiperidine

Xin Ju et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2014)

Article Chemistry, Applied

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase

Naga K. Modukuru et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2014)

Article Biochemistry & Molecular Biology

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

Kazutaka Katoh et al.

MOLECULAR BIOLOGY AND EVOLUTION (2013)

Article Evolutionary Biology

Dendroscope 3: An Interactive Tool for Rooted Phylogenetic Trees and Networks

Daniel H. Huson et al.

SYSTEMATIC BIOLOGY (2012)

Review Chemistry, Multidisciplinary

Enzymatic reductions for the chemist

Frank Hollmann et al.

GREEN CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Practical chiral alcohol manufacture using ketoreductases

Gjalt W. Huisman et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2010)

Article Chemistry, Multidisciplinary

A green-by-design biocatalytic process for atorvastatin intermediate

Steven K. Ma et al.

GREEN CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

An exceptionally DMSO-Tolerant alcohol dehydrogenase for the stereoselective reduction of ketones

Ivan Lavandera et al.

CHEMSUSCHEM (2008)

Review Chemistry, Multidisciplinary

Asymmetric hydrogenation of prochiral amino ketones to amino alcohols for pharmaceutical use

Franz Dietrich Klingler

ACCOUNTS OF CHEMICAL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Cloning, expression, and characterization of an (R)-specific alcohol dehydrogenase from Lactobacillus kefir

Andrea Weckbecker et al.

BIOCATALYSIS AND BIOTRANSFORMATION (2006)

Article Biochemical Research Methods

Protein production by auto-induction in high-density shaking cultures

FW Studier

PROTEIN EXPRESSION AND PURIFICATION (2005)

Article Biotechnology & Applied Microbiology

Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions

B Kosjek et al.

BIOTECHNOLOGY AND BIOENGINEERING (2004)

Article Biochemistry & Molecular Biology

Short-chain dehydrogenases/reductases (SDRs) -: Coenzyme-based functional assignments in completed genomes

Y Kallberg et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Chiral alcohol production by NADH-dependent phenylacetaldehyde reductase coupled with in situ regeneration of NADH

N Itoh et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)