期刊
CEREBRAL CORTEX
卷 31, 期 5, 页码 2466-2481出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa367
关键词
aging; metastability; rich-club; resting-state fMRI; whole-brain dynamics
资金
- Government of Catalonia's Department of Health's Pla Estrategic de Recerca i Innovacio en Salut (PERIS) 2016-2020 [SLT002/16/00250]
- Canon Medical Systems
- Spanish Ministry of Science, Innovation (FEDER funds from the European Union (A way to build Europe)) [RTI2018-099200-B-I00]
- Generalitat of Catalonia [2017SGR696]
- Spanish Ministry of Economy and Competitiveness, Spain (MINECO/AEI/FEDER-EU) [PSI201675688-P]
- European Union [785907]
- Catalan Research Support, Spain [2017 SGR 1545]
- La Marato TV3 [201725.33]
- Catalan project Imagenoma de L'Envelliment (Aging Imageomics Study)
Research indicates that aging leads to alterations in overall brain dynamics, potentially due to a deficiency in a stable substate crucial for efficient global communication in the brain.
Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here, we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50-64 years versus older group (n = 310); age range, 65-91 years). Applying the intrinsic-ignition framework to assess the effect of spontaneous local activation events on local-global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.
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