期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 78, 期 5, 页码 2105-2129出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03696-4
关键词
Inflammation; Tumor microenvironment; Breast cancer; Nanoparticle; Drug targeting; Chemotherapy
资金
- Projects of International Cooperation and Exchanges of National Natural Science Foundation of China [82020108033]
- Natural Science Foundation of Guangdong [2019A1515011286]
- Open Project - Key laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing (2019 Open Project) [05]
- National Natural Science Foundation of China [81973839]
Tumor cells, inflammatory cells, and chemical factors collaborate to form the inflammatory tumor microenvironment, which plays a crucial role in the development of breast cancer. Inflammatory microenvironment contributes to breast cancer growth, metastasis, drug resistance, and angiogenesis through multifactorial mechanisms. Nano-drug delivery system (NDDS) is a popular topic for optimizing tumor targeting drugs, enhancing bioavailability, reducing drug dose, and eliminating off-target side effects.
Tumor cells, inflammatory cells and chemical factors work together to mediate complex signaling networks, which forms inflammatory tumor microenvironment (TME). The development of breast cancer is closely related to the functional activities of TME. This review introduces the origins of cancer-related chronic inflammation and the main constituents of inflammatory microenvironment. Inflammatory microenvironment plays an important role in breast cancer growth, metastasis, drug resistance and angiogenesis through multifactorial mechanisms. It is suggested that inflammatory microenvironment contributes to providing possible mechanisms of drug action and modes of drug transport for anti-cancer treatment. Nano-drug delivery system (NDDS) becomes a popular topic for optimizing the design of tumor targeting drugs. It is seen that with the development of therapeutic approaches, NDDS can be used to achieve drug-targeted delivery well across the biological barriers and into cells, resulting in superior bioavailability, drug dose reduction as well as off-target side effect elimination. This paper focuses on the review of modulation mechanisms of inflammatory microenvironment and combination with nano-targeted therapeutic strategies, providing a comprehensive basis for further research on breast cancer prevention and control.
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