期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 78, 期 6, 页码 2419-2428出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03702-9
关键词
BCL-rambo; Autophagy; Apoptosis; Tumor; Cerebrovascular accident; Neurodegenerative disorders
资金
- National Natural Science Foundation of China [31970701, 21772201, 82072807]
- Anhui Medical University
- Center of Medical Physics and Technology [LHJJ202006, LHJJ202007]
BCL2L13, a BCL2-like protein, has been found to play important roles in both physiological and pathological processes, not only showing pro-apoptotic activity but also influencing cell death and mitophagy.
BCL2L13 is a BCL2-like protein. It has been discovered for two decades, now on the way to be a hotspot of research with its physiological and pathological meanings found in recent years. Start with the pro-apoptotic activity, there have been reported consecutively that BCL2L13 could also induce mitochondrial fragmentation, inhibit cell death and promote mitophagy. Similar to BNIP3, BCL2L13 cannot be indiscriminately categorized into pro- or anti-apoptotic proteins. It anchors in the mitochondrial outer membrane, and expresses in various cells and tissues. This article reviews for the first time that BCL2L13 functions in physiological processes, such as growth and development and energy metabolism, and its dysregulation participating in pathological processes, including cancer, bacterial infection, cardiovascular diseases and degenerative diseases, suggesting its important roles in these events.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据