期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 18, 期 1, 页码 18-37出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-020-00580-w
关键词
T helper; ALD; NAFLD; Fibrosis; Inflammation
类别
资金
- intramural program of the NIAAA (Bin Gao) [U01 AA022614, R01 DK099205, AA011576, AA017729]
The review discusses the important roles of various cytokines in regulating liver disease progression, highlighting the therapeutic potential of some cytokines currently being tested in clinical trials.
Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a variety of factors, including liver injury, inflammatory cells, inflammatory mediators, cytokines, and the gut microbiome. In the current review, we discuss recent data on a large number of cytokines that play important roles in regulating liver injury, inflammation, fibrosis, and regeneration, with a focus on interferons and T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 family, and IL-20 family cytokines. Hepatocytes can also produce certain cytokines (such as IL-7, IL-11, and IL-33), and the functions of these cytokines in the liver are briefly summarized. Several cytokines have great therapeutic potential, and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases, which are also described.
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