期刊
CELL METABOLISM
卷 32, 期 6, 页码 905-907出版社
CELL PRESS
DOI: 10.1016/j.cmet.2020.11.004
关键词
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资金
- PUMC Fundamental Research Funds for the Central Universities [3332019113]
- National Natural Science Foundation of China [31900645, 81972875, 81971466]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT310028]
- Innovation Fund from the Chinese Academy of Medical Sciences [2016-I2M-1-005]
Two recent studies published in Nature Immunology map out the link between dysregulated mitochondrial metabolism and terminal exhaustion of tumor-infiltrating T lymphocytes. Yu et al. (2020) and Vardhana et al. (2020) show that defective mitophagy or impaired oxidative phosphorylation triggers mitochondrial reactive oxygen species production, which in turn promotes a T cell exhaustion program, limiting T cell proliferation and self-renewal.
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