4.8 Article

Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis

期刊

CELL METABOLISM
卷 33, 期 2, 页码 -

出版社

CELL PRESS
DOI: 10.1016/j.cmet.2020.11.019

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资金

  1. Key Research and Development Program focused on Stem Cell and Translational Research [2016YFA0101600]
  2. National Natural Science Foundation of China [91639117, 81925005, 91839301, 81722005]
  3. National Heart Lung and Blood Institute [UM1 HL120877]

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Aging impairs regenerative capacity and leads to fibrosis in organs. Aberrant reprogramming of hematopoietic and vascular cell crosstalk in aging hinders regeneration and promotes fibrosis. Targeting aberrant endothelial node molecules may facilitate regeneration without scarring in the repair of multiple organs.
Regenerative capacity is frequently impaired in aged organs. Stress to aged organs often causes scar formation (fibrosis) at the expense of regeneration. It remains to be defined how hematopoietic and vascular cells contribute to aging-induced regeneration to fibrotic transition. Here, we find that aging aberrantly reprograms the crosstalk between hematopoietic and vascular cells to impede the regenerative capacity and enhance fibrosis. In aged lung, liver, and kidney, induction of Neuropilin-1/hypoxia-inducible-factor 2 alpha (HIF2 alpha) suppresses anti-thrombotic and anti-inflammatory endothelial protein C receptor (EPCR) pathway, leading to formation of pro-fibrotic platelet-macrophage rosette. Activated platelets via supplying interleukin 1 alpha synergize with endothelial-produced angiocrine chemokine to recruit fibrogenic TIMP1(high) macrophages. In mouse models, genetic targeting of endothelial Neuropilin-1-HIF2 alpha, platelet interleukin 1 alpha, or macrophage TIMP1 normalized the pro-fibrotic hematopoietic-vascular niche and restored the regenerative capacity of old organs. Targeting of aberrant endothelial node molecules might help propel regeneration without scarring'' in the repair of multiple organs.

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