期刊
CELL DEATH AND DIFFERENTIATION
卷 28, 期 6, 页码 1790-1803出版社
SPRINGERNATURE
DOI: 10.1038/s41418-020-00701-y
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean government (MIST) [2019R1A2C2084181, 2020R1A4A1016029]
- National Research Foundation of Korea [2020R1A4A1016029, 2019R1A2C2084181] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
TRIM28 is often overexpressed in lung cancer patients and regulates the levels of p53 by targeting ubiquitin ligases RLIM and MDM2, affecting proliferation, migration, and invasiveness of lung cancer cells.
Tripartite motif-containing 28 (TRIM28) is an E3 ubiquitin ligase harboring multiple cellular functions. We found that the TRIM28 protein is frequently overexpressed in patients with lung cancer. The stable overexpression of TRIM28 in lung cancer cells and xenograft models significantly increased the proliferation, migration, and invasiveness, whereas knockdown of TRIM28 had the opposite effect. We further observed that TRIM28 regulates the ubiquitin ligases RLIM and MDM2 to target the p53 levels during lung tumorigenesis. These data provide new insights into lung cancer development and potential new therapeutic targets for this disease.
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