期刊
CELL COMMUNICATION AND SIGNALING
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12964-020-00693-9
关键词
Toll-like receptors; TLRs; Phosphatases; NF-kappa B; IRFs axis; IFN I; MAPK
类别
资金
- FRQS-Funded Centre de Recherche du CHUS
- Canadian Research Chair in colorectal cancer and inflammatory cell signaling
- Canadian Institutes of Health Research [MOP 119593]
Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
Over the past 2 decades, pattern recognition receptors (PRRs) have been shown to be on the front line of many illnesses such as autoimmune, inflammatory, and neurodegenerative diseases as well as allergies and cancer. Among PRRs, toll-like receptors (TLRs) are the most studied family. Dissecting TLRs signaling turned out to be advantageous to elaborate efficient treatments to cure autoimmune and chronic inflammatory disorders. However, a broad understanding of TLR effectors is required to propose a better range of cures. In addition to kinases and E3 ubiquitin ligases, phosphatases emerge as important regulators of TLRs signaling mediated by NF-kappa B, type I interferons (IFN I) and Mitogen-Activated Protein Kinases signaling pathways. Here, we review recent knowledge on TLRs signaling modulation by different classes and subclasses of phosphatases. Thus, it becomes more and more evident that phosphatases could represent novel therapeutic targets to control pathogenic TLRs signaling.
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