期刊
CELL COMMUNICATION AND SIGNALING
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12964-020-00659-x
关键词
Mitophagy; Mitochondrial stress; Innate immunity; Infection; Mitophagy mechanisms
类别
资金
- National Natural Science Foundation of China [31873005]
- China Agriculture Research System [CARS-36]
- National Key Research and Development Program [2017YFD0500901]
Mitochondria are important cellular organelles involved in many different functions, from energy generation and fatty acid oxidation to cell death regulation and immune responses. Accumulating evidence indicates that mitochondrial stress acts as a key trigger of innate immune responses. Critically, the dysfunctional mitochondria can be selectively eliminated by mitophagy. The elimination of dysfunctional mitochondria may function as an effective way employed by mitophagy to keep the immune system in check. In addition, mitophagy can be utilized by pathogens for immune evasion. In this review, we summarize how mitochondrial stress triggers innate immune responses and the roles of mitophagy in innate immunity and in infection, as well as the molecular mechanisms of mitophagy.
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