期刊
CELL BIOLOGY INTERNATIONAL
卷 45, 期 4, 页码 708-719出版社
WILEY
DOI: 10.1002/cbin.11527
关键词
biomarker; cancer; epigenetics; methylation; processing‐ body; stress granules
类别
资金
- Department of Biotechnology, Ministry of Science and Technology [BT/PR23887/MED/30/1871/2017]
Processing bodies (PBs) are cytoplasmic messenger ribonucleoprotein particle granules involved in eukaryotic gene expression regulation. They are maintained by RNA-protein and protein-protein interactions and undergo dynamic changes in response to cellular cues, including viral infections. Some PB proteins are implicated in cancer development, but the effects of epigenetic modifications on cancer-associated PB genes on PB dynamics remain to be fully explored.
Processing bodies (PBs) are 100-300 nm cytoplasmic messenger ribonucleoprotein particle (mRNP) granules that regulate eukaryotic gene expression. These cytoplasmic compartments harbor messenger RNAs (mRNAs) and several proteins involved in mRNA decay, microRNA silencing, nonsense-mediated mRNA decay, and splicing. Though membrane-less, PB structures are maintained by RNA-protein and protein-protein interactions. PB proteins have intrinsically disordered regions and low complexity domains, which account for its liquid to liquid phase separation. In addition to being dynamic and actively involved in the exchange of materials with other mRNPs and organelles, they undergo changes on various cellular cues and environmental stresses, including viral infections. Interestingly, several PB proteins are individually implicated in cancer development, and no study has addressed the effects on PB dynamics after epigenetic modifications of cancer-associated PB genes. In the current review, we summarize modulations undergone by P bodies or P body components upon viral infections. Furthermore, we discuss the selective and widely investigated PB proteins that undergo methylation changes in cancer and their potential as biomarkers.
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