期刊
CELL AND TISSUE RESEARCH
卷 383, 期 1, 页码 387-393出版社
SPRINGER
DOI: 10.1007/s00441-020-03393-5
关键词
-
类别
资金
- University of Geneva
Variations in gene expression patterns play a powerful role in evolutionary innovation. An evolutionary event led an immune pathogen sensor to transition into an olfactory chemoreceptor, shifting its function from sensing the internal world to exploring the external world.
Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sensor to transition into an olfactory chemoreceptor, which thus moved from sensing the internal world to probing the outside world. We here discuss the evolution of the FPR gene family, the events that led to their neofunctionalization in the vomeronasal organ and the functions of immune and vomeronasal FPRs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据