Processing of intraspecific chemical signals in the rodent brain

In the rodent brain, the central processing of ecologically relevant chemical stimuli involves many different areas located at various levels within the neuraxis: the main and accessory olfactory bulbs, some nuclei in the amygdala, the hypothalamus, and brainstem. These areas allow the integration of the chemosensory stimuli with other sensory information and the selection of the appropriate neurohormonal and behavioral response. This review is a brief introduction to the processing of intraspecific chemosensory stimuli beyond the secondary projection, focusing on the activity of the relevant amygdala and hypothalamic nuclei, namely the medial amygdala and ventromedial hypothalamus. These areas are involved in the appropriate interpretation of chemosensory information and drive the selection of the proper response, which may be behavioral or hormonal and may affect the neural activity of other areas in the telencephalon and brainstem. Recent data support the notion that the processing of intraspecific chemical signals is not unique to one chemosensory system and some molecules may activate both the main and the accessory olfactory system. Moreover, both these systems have mixed projections and cooperate for the correct identification of the stimuli and selection of relevant responses.

Automated summary

In the rodent brain, the central processing of ecologically relevant chemical stimuli involves various areas at different levels, including the main and accessory olfactory bulbs, nuclei in the amygdala, hypothalamus, and brainstem. Recent data suggests that processing of intraspecific chemical signals is not unique to one system, with some molecules activating both the main and accessory olfactory systems. These areas work together to interpret chemosensory information and drive appropriate responses, affecting neural activity in other areas of the brain.