期刊
CELL AND TISSUE RESEARCH
卷 383, 期 1, 页码 507-524出版社
SPRINGER
DOI: 10.1007/s00441-020-03365-9
关键词
Olfactory bulb; Neuromodulation; Rodents; Olfactory processing; Perception
类别
资金
- DFG [RO4046/2-1, RO4046/2-2]
- Research Training Group MultiSenses-MultiScales: novel approaches to decipher neural processing in multisensory integration [368482240/GRK2416]
- Interdisciplinary Center for Clinical Research within the faculty of Medicine at the RWTH Aachen University [IZKF TN1-7532007]
- Projekt DEAL
This passage explores neuromodulatory processes in the rodent OB from extrinsic sources, including points of origin, receptors involved, affected circuits, and changes in behavior.
Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual's health and survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to heavily process sensory information. To adapt to an animal's needs, OB activity can be influenced by many factors either from within (intrinsic neuromodulation) or outside (extrinsic neuromodulation) the OB which include neurotransmitters, neuromodulators, hormones, and neuropeptides. Extrinsic sources seem to be of special importance as the OB receives massive efferent input from numerous brain centers even outweighing the sensory input from the nose. Here, we review neuromodulatory processes in the rodent OB from such extrinsic sources. We will discuss extrinsic neuromodulation according to points of origin, receptors involved, affected circuits, and changes in behavior. In the end, we give a brief outlook on potential future directions in research on neuromodulation in the OB.
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