期刊
CELL
卷 184, 期 2, 页码 422-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.12.033
关键词
-
资金
- In Vivo Imaging Core (IVIC) at the Washington University School of Medicine
- NIAMS [K08-AR065577, R01-AR070116, R01-AR060962, R01-AR070873]
- American Skin Association
- Doris Duke Charitable Foundation
- LEO Pharma
- NIAID [R01-AI077600, T32-AI716339]
- NIAID NRSA [F30 AI154912]
- Dermatology Foundation Dermatologist Investigator Research Fellowship (DIRF)
- NCI Cancer Center support grant [P30CA91842]
The study identifies that a large proportion of patients with atopic dermatitis (AD) harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. It also shows that in AD-associated inflammation, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares.
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitating. In addition to chronic itch, patients often experience intense acute itch exacerbations. Recent discoveries have unearthed the neuroimmune circuitry of itch, leading to the development of anti-itch treatments. However, mechanisms underlying acute itch exacerbations remain overlooked. Herein, we identify that a large proportion of patients with AD harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. In mice, while allergen-provoked acute itch is mediated by the mast cell-histamine axis in steady state, AD-associated inflammation renders this pathway dispensable. Instead, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares. By probing fundamental itch mechanisms, our study highlights a basophil-neuronal circuit that may underlie a variety of neuroimmune processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据