The Rise of Molecular Glues

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as molecular glues'' that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.

Automated summary

The 30th anniversary of the discovery of cyclosporin A and FK506 marks a milestone in understanding their role as molecular glues that induce new protein-protein interactions. The emergence of new molecular-glue probes and medications has sparked interest in this field.