期刊
CARDIOVASCULAR RESEARCH
卷 117, 期 12, 页码 2416-2433出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvab009
关键词
Heart failure; Multi-organ clinical syndrome; Lung; Intestine; Kidney; Brain; Adipose tissue; Liver; Non-coding RNAs
资金
- British Heart Foundation [PG/17/64/33205]
- European Union Commission's Seventh Framework program [305507]
- EU [825670]
- ERA-Net-CVD project MacroERA [01KL1706]
- IMI2CARDIATEAM [821508]
- Netherlands Cardiovascular Research Initiative
- Dutch Heart Foundation [2015-10, 2017-21, 2017-18, 2018-28, 2012-06, 2014-20]
- Research Foundation Flanders FWO [G091018N, G0B5930N]
- Deutsche Forschungsgemeinschaft [KFO311/TH903/20]
- AIRC [IG 2016 19032]
- Dutch Federation of University Medical Centres
- Netherlands Organisation for Health Research and Development
- Royal Netherlands Academy of Sciences
- Netherlands Organization for Sciences-ZonMW [VICI 91818602]
- Project NETDIAMOND - European Structural and Investment Funds [POCI-01-0145-FEDER-016385]
- Lisbon's Regional Operational Program 2020
- Portuguese Foundation for Science and Technology
Heart failure, whether with reduced or preserved ejection fraction, is a clinical syndrome with symptoms such as shortness of breath, fatigue, and edema, impacting multiple organ systems. Patients with advanced heart failure have a limited life expectancy, highlighting the need for further experimental research to explore treatment options.
Heart failure-either with reduced or preserved ejection fraction (HFrEF/HFpEF)-is a clinical syndrome of multi-factorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body's needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.
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