Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm

The coronavirus disease 19 (COVID-19) pandemic poses a serious global threat to human health and the economy. Based on accumulating evidence, its continuous progression involves not only pulmonary injury but also damage to the cardiovascular system due to intertwined pathophysiological risks. As a point of convergence in the pathophysiologic process between COVID-19 and heart failure (HF), cytokine storm induces the progression of COVID-19 in patients presenting pre-existing or new onset myocardial damage and even HF. Cytokine storm, as a trigger of the progression of HF in patients with COVID-19, has become a novel focus to explore therapies for target populations. In this review, we briefly introduce the basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illuminate the mechanism and links among COVID-19, cytokine storm, and HF. Furthermore, we discuss drugs and therapeutic targets for patients with COVID-19 and HF.

Automated summary

The COVID-19 pandemic poses a global threat to health and economy, with accumulating evidence showing damage not only to the lungs but also to the cardiovascular system. Cytokine storm plays a key role in the progression of COVID-19, especially in patients with pre-existing or new onset myocardial damage and heart failure, making it a novel focus for therapies.