相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The TGF-β pathway plays a key role in aortic aneurysms
Tang Tingting et al.
CLINICA CHIMICA ACTA (2020)
Meta-analysis Examining the Usefulness of Angiotensin Receptor blockers for the Prevention of Aortic Root Dilation in Patients With the Marfan Syndrome
Abdullah Al-abcha et al.
AMERICAN JOURNAL OF CARDIOLOGY (2020)
Extracellular Matrix in Vascular Disease, Part 2/4
Javier Barallobre-Barreiro et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)
Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial
Mitzi M. van Andel et al.
EUROPEAN HEART JOURNAL (2020)
Long-term clinical outcomes of losartan in patients with Marfan syndrome: fallow-up of the multicentre randomized controlled COMPARE trial
Mitzi M. van Andel et al.
EUROPEAN HEART JOURNAL (2020)
Novel pathogenic SMAD2 variants in five families with arterial aneurysm and dissection: further delineation of the phenotype
Elyssa Cannaerts et al.
JOURNAL OF MEDICAL GENETICS (2019)
Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome A Review
Marion A. Hofmann Bowman et al.
JAMA CARDIOLOGY (2019)
6128Losartan vs Nebivolol vs the association of both on the progression of aortic root dilation in genotyped Marfan Syndrome: 48 months open label randomized controlled phase III trial
A Di Toro et al.
EUROPEAN HEART JOURNAL (2019)
Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections Old Controversies and New Opportunities
Dianna M. Milewicz et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)
Reversal of Aortic Enlargement Induced by Increased Biomechanical Forces Requires AT1R Inhibition in Conjunction With AT2R Activation
Zhen Zhou et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome
Elena Gallo MacFarlane et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial
Michael Mullen et al.
LANCET (2019)
First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study
Ryan J. Sullivan et al.
CANCER DISCOVERY (2018)
Causes of Mortality in the Marfan Syndrome (from a Nationwide Register Study)
Kristian A. Groth et al.
AMERICAN JOURNAL OF CARDIOLOGY (2018)
Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal DiseaseBrief Report
Josephine Galatioto et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation
Ingrid van der Pluijm et al.
CARDIOVASCULAR RESEARCH (2018)
Targeted genetic analysis in a large cohort of familial and sporadic cases of aneurysm or dissection of the thoracic aorta
Ruwan Weerakkody et al.
GENETICS IN MEDICINE (2018)
The Effect of a Nonpeptide Angiotensin II Type 2 Receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome
Peter Verbrugghe et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2018)
ANGIOTENSIN II SIGNAL TRANSDUCTION: AN UPDATE ON MECHANISMS OF PHYSIOLOGY AND PATHOPHYSIOLOGY
Steven J. Forrester et al.
PHYSIOLOGICAL REVIEWS (2018)
TGF-β receptors: In and beyond TGF-β signaling
Alexandra Vander Ark et al.
CELLULAR SIGNALLING (2018)
Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans
Yoshito Yamashiro et al.
CIRCULATION RESEARCH (2018)
Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome
Gisela Teixido-Tura et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
Aortic Dimensions and Clinical Outcome in Patients With SMAD3 Mutations
A. T. van den Hoven et al.
CIRCULATION-GENOMIC AND PRECISION MEDICINE (2018)
Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections
Josephina A. N. Meester et al.
GENETICS IN MEDICINE (2017)
An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death
Alessandra Granata et al.
NATURE GENETICS (2017)
Signaling Cross Talk between TGF-beta/Smad and Other Signaling Pathways
Kunxin Luo
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Non-Smad Signaling Pathways of the TGF-β Family
Ying E. Zhang
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Relationship between fibrillin-1 genotype and severity of cardiovascular involvement in Marfan syndrome
Romy Franken et al.
HEART (2017)
SMAD4 gene mutation increases the risk of aortic dilation in patients with hereditary haemorrhagic telangiectasia
V. M. M. Vorselaars et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)
Aetiology and management of hereditary aortopathy
Aline Verstraeten et al.
NATURE REVIEWS CARDIOLOGY (2017)
TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Elena Gallo MacFarlane et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?
Alan Daugherty et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)
Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor
Elisabeth Gillis et al.
FRONTIERS IN PHYSIOLOGY (2017)
Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
Josephina A. N. Meester et al.
ANNALS OF CARDIOTHORACIC SURGERY (2017)
Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial
Laura Muino-Mosquera et al.
ACTA CARDIOLOGICA (2017)
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice
Smriti Murali Krishna et al.
CLINICAL SCIENCE (2017)
Efficacy of losartan vs. atenolol for the prevention of aortic dilation in Marfan syndrome: a randomized clinical trial
Alberto Forteza et al.
EUROPEAN HEART JOURNAL (2016)
A Decade of Discovery in the Genetic Understanding of Thoracic Aortic Disease
Gregor Andelfinger et al.
CANADIAN JOURNAL OF CARDIOLOGY (2016)
Hereditary Influence in Thoracic Aortic Aneurysm and Dissection
Eric M. Isselbacher et al.
CIRCULATION (2016)
Pathogenic FBN1 variants in familial thoracic aortic aneurysms and dissections
E. S. Regalado et al.
CLINICAL GENETICS (2016)
The incidence and mortality of acute thoracic aortic dissection: results from a whole nation study
Inga H. Melvinsdottir et al.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2016)
AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice
Luuk te Riet et al.
JOURNAL OF HYPERTENSION (2016)
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa
Takako Sasaki et al.
MATRIX BIOLOGY (2016)
TGF-β Signaling from Receptors to Smads
Akiko Hata et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling
I. van der Pluijm et al.
EBIOMEDICINE (2016)
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
Xiaofeng Chen et al.
PLOS ONE (2016)
Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration
Alex Pitcher et al.
AMERICAN HEART JOURNAL (2015)
Divergent Roles of Matrix Metalloproteinase 2 in Pathogenesis of Thoracic Aortic Aneurysm
Mengcheng Shen et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta
Aruna Poduri et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice
Jie Hong Hu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome
Jason R. Cook et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)
Role of Mechanotransduction in Vascular Biology Focus on Thoracic Aortic Aneurysms and Dissections
Jay D. Humphrey et al.
CIRCULATION RESEARCH (2015)
Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome
Romy Franken et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Marfan Sartan: a randomized, double-blind, placebo-controlled trial
Olivier Milleron et al.
EUROPEAN HEART JOURNAL (2015)
SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections
Dimitra Micha et al.
HUMAN MUTATION (2015)
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities
Olga Igoucheva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Angiotensin II Induces an Increase in Matrix Metalloproteinase 2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic Aneurysms Through JNK, ERK1/2, and p38 MAPK Activation
Chunmao Wang et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2015)
Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
Aida M. Bertoli-Avella et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)
Latent TGF-β-binding proteins
Ian B. Robertson et al.
MATRIX BIOLOGY (2015)
Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice
Yoshito Yamashiro et al.
SCIENCE SIGNALING (2015)
Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels
N. W. M. Ramnath et al.
SCIENTIFIC REPORTS (2015)
Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome
Romy Franken et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2015)
Abnormal mechanosensing and cofilin activation promotes the progression of ascending aortic aneurysms in mice
Yoshito Yamashiro et al.
SCIENCE SIGNALING (2015)
The Comparative Efficacy and Safety of the Angiotensin Receptor Blockers in the Management of Hypertension and Other Cardiovascular Diseases
Hazel Mae A. Abraham et al.
DRUG SAFETY (2015)
The revised role of TGF-β in aortic aneurysms in Marfan syndrome
R. Franken et al.
NETHERLANDS HEART JOURNAL (2015)
Angiotensin II Induces Region-Specific Medial Disruption during Evolution of Ascending Aortic Aneurysms
Debra L. Rateri et al.
AMERICAN JOURNAL OF PATHOLOGY (2014)
MCP-1 Stimulates MMP-9 Expression via ERK 1/2 and p38 MAPK Signaling Pathways in Human Aortic Smooth Muscle Cells
Ci-Qiu Yang et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
2014 ESC Guidelines on the diagnosis and treatment of aortic diseases
Raimund Erbel et al.
EUROPEAN HEART JOURNAL (2014)
Loeys-Dietz syndrome: a primer for diagnosis and management
Gretchen MacCarrick et al.
GENETICS IN MEDICINE (2014)
Retrospective analysis of the effect of angiotensin II receptor blocker versus β-blocker on aortic root growth in paediatric patients with Marfan syndrome
Goetz C. Mueller et al.
HEART (2014)
Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
Elena M. Gahllo et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis
Wei Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome
R. V. Lacro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Dysfunctional Mechanosensing in Aneurysms
Jay D. Humphrey et al.
SCIENCE (2014)
Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells
Jelena Krstic et al.
SCIENTIFIC WORLD JOURNAL (2014)
Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms
Xiaofeng Chen et al.
CURRENT OPINION IN PHARMACOLOGY (2013)
Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial
Maarten Groenink et al.
EUROPEAN HEART JOURNAL (2013)
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency
Ping Ye et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Important role of the angiotensin II pathway in producing matrix metalloproteinase-9 in human thoracic aortic aneurysms
Ayako Nagasawa et al.
JOURNAL OF SURGICAL RESEARCH (2013)
Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic aneurysms
Tuija Huusko et al.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2013)
Losartan Added to β-Blockade Therapy for Aortic Root Dilation in Marfan Syndrome: A Randomized, Open-Label Pilot Study
Hsin-Hui Chiu et al.
MAYO CLINIC PROCEEDINGS (2013)
PD123319 Augments Angiotensin II-Induced Abdominal Aortic Aneurysms through an AT2 Receptor-Independent Mechanism
Alan Daugherty et al.
PLOS ONE (2013)
Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice
Jianbin Huang et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Regulation of Peroxisome Proliferator-Activated Receptor-γ by Angiotensin II Via Transforming Growth Factor-β1-Activated p38 Mitogen-Activated Protein Kinase in Aortic Smooth Muscle Cells
Venkateswaran Subramanian et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Role of Smads in TGF beta signaling
Carl-Henrik Heldin et al.
CELL AND TISSUE RESEARCH (2012)
Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome
Ingrid M. B. H. van de Laar et al.
JOURNAL OF MEDICAL GENETICS (2012)
Structure and function of the mammalian fibrillin gene family: Implications for human connective tissue diseases
Margaret R. Davis et al.
MOLECULAR GENETICS AND METABOLISM (2012)
TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome
Catherine Boileau et al.
NATURE GENETICS (2012)
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
Alexander J. Doyle et al.
NATURE GENETICS (2012)
TGFβ signalling in context
Joan Massague
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Endothelial Cell-Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II-Induced Ascending Aortic Aneurysms in LDL Receptor-/- Mice
Debra L. Rateri et al.
CIRCULATION RESEARCH (2011)
Lessons on the pathogenesis of aneurysm from heritable conditions
Mark E. Lindsay et al.
NATURE (2011)
Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
Ingrid M. B. H. van de laar et al.
NATURE GENETICS (2011)
Epidemiology of thoracic aortic dissection
Scott A. LeMaire et al.
NATURE REVIEWS CARDIOLOGY (2011)
The role of the renin-angiotensin system in thoracic aortic aneurysms: Clinical implications
Els Moltzer et al.
PHARMACOLOGY & THERAPEUTICS (2011)
Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
Tammy M. Holm et al.
SCIENCE (2011)
Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism
Jennifer P. Habashi et al.
SCIENCE (2011)
Fibulin-4 Deficiency Results in Ascending Aortic Aneurysms A Potential Link Between Abnormal Smooth Muscle Cell Phenotype and Aneurysm Progression
Jianbin Huang et al.
CIRCULATION RESEARCH (2010)
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
Alan Daugherty et al.
CLINICAL SCIENCE (2010)
In Vivo Studies of Mutant Fibrillin-1 Microfibrils
Noe L. Charbonneau et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
TGF-β in the pathogenesis and prevention of disease: a matter of aneurysmic proportions
Harry C. Dietz
JOURNAL OF CLINICAL INVESTIGATION (2010)
TGF-β signaling in aortic aneurysm: another round of controversy
Fuyu Lin et al.
JOURNAL OF GENETICS AND GENOMICS (2010)
The angiotensin II type 2 receptor in cardiovascular disease
Catherine A. Lemarie et al.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2010)
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome
H. H. Clarice Yang et al.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2010)
β-Arrestin-Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress
Kriti Rakesh et al.
SCIENCE SIGNALING (2010)
Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects
Dominique Langlois et al.
TRANSGENIC RESEARCH (2010)
Histopathologic Findings in Ascending Aortas From Individuals With Loeys-Dietz Syndrome (LDS)
Joseph J. Maleszewski et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2009)
TGF-beta signaling in vascular biology and dysfunction
Marie-Jose Goumans et al.
CELL RESEARCH (2009)
Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms
Alun Jones et al.
CIRCULATION (2009)
Circulating Transforming Growth Factor-β in Marfan Syndrome
Peter Matt et al.
CIRCULATION (2009)
Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling
Francesco Ramirez et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
TGF-β3 and cancer: A review
H. G. Laverty et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2009)
Absence of TGFβ Signaling in Embryonic Vascular Smooth Muscle Leads to Reduced Lysyl Oxidase Expression, Impaired Elastogenesis, and Aneurysm
Bibha Choudhary et al.
GENESIS (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of matrix metalloproteinase-2 and-9
Ada W. Y. Chung et al.
CIRCULATION RESEARCH (2008)
Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
Wanfen Xiong et al.
JOURNAL OF VASCULAR SURGERY (2008)
Angiotensin II blockade and aortic-root dilation in Marfan's syndrome
Benjamin S. Brooke et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
The many faces of aggressive aortic pathology: Loeys-Dietz syndrome
J. J. J. Aalberts et al.
NETHERLANDS HEART JOURNAL (2008)
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFβ receptors in mice
Rita L. C. Carvalho et al.
JOURNAL OF CELL SCIENCE (2007)
Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
Dong-Chuan Guo et al.
NATURE GENETICS (2007)
TGF-β signaling:: A tale of two responses
Rod A. Rahimi et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Effect of mutation type and location on clinical outcome in 1,013 probands with Marfan syndrome or related phenotypes and FBN1 mutations:: An international study
L. Faivre et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors
Kouichiro Goto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Biglycan deficiency causes spontaneous aortic dissection and rupture in mice
Anne-Marie Heegaard et al.
CIRCULATION (2007)
TGF-β signaling in vascular fibrosis
Marta Ruiz-Ortega et al.
CARDIOVASCULAR RESEARCH (2007)
Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice
Katsuhiro Hanada et al.
CIRCULATION RESEARCH (2007)
Fibrillin-1 regulates the bioavailability of TGFβ1
Shazia S. Chaudhry et al.
JOURNAL OF CELL BIOLOGY (2007)
Marfan syndrome: An update of genetics, medical and surgical management
Yskert von Kodolitsch et al.
HEART (2007)
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
Jikui Wang et al.
BMC DEVELOPMENTAL BIOLOGY (2006)
Familial thoracic aortic aneurysms and dissections - Incidence, modes of inheritance, and phenotypic patterns
Gonzalo Albornoz et al.
ANNALS OF THORACIC SURGERY (2006)
Aneurysm syndromes caused by mutations in the TGF-β receptor
Bart L. Loeys et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Fibulin-4:: A novel gene for an autosomal recessive cutis laxa syndrome
Vishwanathan Hucthagowder et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2006)
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
JP Habashi et al.
SCIENCE (2006)
Fibrillins 1 and 2 perform partially overlapping functions during aortic development
L Carta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice
PJ McLaughlin et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and fibronectin
V Baron et al.
CANCER GENE THERAPY (2006)
Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFβ receptor (Tgfbr2) mutant mice
B Choudhary et al.
DEVELOPMENTAL BIOLOGY (2006)
Neutralization of transforming growth factor-β attenuates hypertension and prevents renal injury in uremic rats
P Lavoie et al.
JOURNAL OF HYPERTENSION (2005)
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-β-independent mechanism
J Rodríguez-Vita et al.
CIRCULATION (2005)
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
BL Loeys et al.
NATURE GENETICS (2005)
Aortic stiffness and diameter predict progressive aortic dilatation in patients with Marfan syndrome
GJ Nollen et al.
EUROPEAN HEART JOURNAL (2004)
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome
DP Judge et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
c-Ski inhibits the TGF-β signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements
H Suzuki et al.
ONCOGENE (2004)
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
YZ Zou et al.
NATURE CELL BIOLOGY (2004)
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
ER Neptune et al.
NATURE GENETICS (2003)
Latent transforming growth factor β-binding protein 1 interacts with fibrillin and is a microfibril-associated protein
Z Isogai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Making sense of latent TGFβ activation
JP Annes et al.
JOURNAL OF CELL SCIENCE (2003)
Angiotensin AT(2) receptors: cardiovascular hope or hype?
RE Widdop et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Update of the UMD-FBN1 mutation database and creation of an FBN1 polymorphlism database
G Collod-Beroud et al.
HUMAN MUTATION (2003)
Natural history of thoracic aortic aneurysms: Indications for surgery, and surgical versus nonsurgical risks
JA Elefteriades
ANNALS OF THORACIC SURGERY (2002)
Yearly rupture or dissection rates for thoracic aortic aneurysms: Simple prediction based on size
RR Davies et al.
ANNALS OF THORACIC SURGERY (2002)
The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling
A Hanyu et al.
JOURNAL OF CELL BIOLOGY (2001)
Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
J Larsson et al.
EMBO JOURNAL (2001)
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice
A Daugherty et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Shear stress induces angiotensin converting enzyme expression in cultured smooth muscle cells: possible involvement of bFGF
W Gosgnach et al.
CARDIOVASCULAR RESEARCH (2000)
分享论文
