Light-tuning amphiphility of host-guest Alginate-based supramolecular assemblies for photo-responsive Pickering emulsions

Various Pickering emulsions-based system have been increasing demand for potential applications in a wide variety of fields. However, tunable emulsifiers and controllable Pickering emulsions with the ability to respond to external triggers remains an outstanding challenge. Here, we demonstrate the photo-tuning amphiphilicity in Pickering emulsions using beta-cyclodextrin-grafted alginate and azobenzene derivative supramolecular self-assemblies as photoactivatable emulsifiers. Specifically, the photoisomerization of a host-guest system between beta-cyclodextrin and azobenzene derivative was employed to tailor the polarity of the microenvironment, resulting in the reversible variation of hydrophilic/hydrophobic balance. The photoactivatable emulsifier based on supramolecular self-assemblies could effectively destabilize o/w emulsions by tailoring the amphiphilic balance at oil-water interface under an external UV irradiation, leading to the oil-water separation from Pickering emulsion. The light regulating demulsification is further showcased here by the photodelivery of hydrophobic model drug. Finally, this study provides a sustainable yet eco-friendly formulation for the fabrication of stimuli-responsive Pickering emulsions.

Automated summary

This study demonstrates the photo-tuning amphiphilicity in Pickering emulsions using beta-cyclodextrin-grafted alginate and azobenzene derivative supramolecular self-assemblies as photoactivatable emulsifiers. By employing the photoisomerization of a host-guest system, the polarity of the microenvironment can be tailored, resulting in reversible variation of hydrophilic/hydrophobic balance and oil-water separation in Pickering emulsions with external UV irradiation. This provides a sustainable and eco-friendly formulation for the fabrication of stimuli-responsive Pickering emulsions.