期刊
CARBOHYDRATE POLYMERS
卷 251, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117005
关键词
pectin; chitosan; injectable hydrogel; Schiff-base reaction; wound healing
资金
- Shenzhen Fundamental Research Funds [JCYJ20170302145500980, JCYJ20170818100526471, KQJSCX20 180328095512554]
- Medical Scientific Research Foundation of Guangdong Province [A2018555]
- Nanshan District Key Lab for Biopolymers and Safety Evaluation [KC2014ZDZJ0001A]
- Shenzhen Sci & Tech research grant [ZDSYS201507141105130]
By adjusting the content of amine and aldehyde groups from AP and OC, the properties of the hydrogel can be controlled to have desirable gelation time, swelling capability, high hemocompatibility and biocompatibility. The AP-OC-65 hydrogel, in particular, stands out with superior swelling capability and better hemo- and bio-compatibility, showing great potential for applications in wound dressing or skin substitute.
Hydrogel can provide a favorable moisture environment for skin wound healing. In this study, a novel in-situ crosslinked injectable hydrogel was prepared using the water-soluble amidated pectin (AP) and oxidized chitosan (OC) through Schiff-base reaction without any chemical crosslinker. The influence of AP content on the properties of the hydrogel was systemically investigated. It showed that gelation time, pore structure, swelling capability and degradability of the hydrogel can be tuned by varying the content of amine and aldehyde groups from AP and OC. All the porous hydrogels with various AP contents (65%, 70%, and 80%) presented desirable gelation time, swelling property, high hemocompatibility and biocompatibility. Particularly, AP-OC-65 hydrogel presented superior swelling capability and better hemo- and bio-compatibility, owing to more residual amine sites in the hydrogel. Therefore, the injectable AP-OC-65 hydrogel has a greater potential for application to wound dressing or skin substitute.
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