期刊
CARBOHYDRATE POLYMERS
卷 251, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116930
关键词
Hericium erinaceus polysaccharide; Morphological; Features; Cyclophosphamide-induced immunosuppression; Splenocyte; Immunomodulatory
资金
- Department of Science and Technology of Guangdong Province, China [2013B090600008]
- Medical Scientific Research Foundation of Guangdong Province, China [B2020190]
The hetem polysaccharide fraction (HEP-W) from Hericium erinaceus displayed a flexible random coil conformation and continuous fiber network structure, showing immunomodulatory activities by enhancing immune responses in mice. This suggests that HEP-W could be explored as a natural and effective immunomodulatory agent.
The aim of this study was to investigate the surface morphological features and in vivo immunomodulatory activities of a hetem polysaccharide fraction (HEP-W) from Hericium erinaceus. SEM and AFM images revealed that HEP-W displayed a flexible random coil conformation, and these flexible winding chains further formed continuous fiber network structure. Meanwhile, Congo red assay and XRD further proved that HEP-W mainly exhibited amorphous structure with non-triple-helical conformation in solution. In vivo immunomodulatory experiments demonstrated that HEP-W possessed protective effects against cyclophosphamide-induced immunosuppression in mice by significantly enhancing immune organ index, splenocyte proliferation, NK cell activity, IL-2 production as well as improving the macrophage phagocytosis. These findings suggest that HEP-W could be explored as a natural and effective immunomodulatory agent.
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