4.6 Review

MYC as a target for cancer treatment

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Article Oncology

The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells

Dalal AlSultan et al.

Summary: The MYC oncogene is a common driver gene in cancer, making it a potential target for cancer treatment and a biomarker for the disease. A novel MYC inhibitor, MYCMI-6, was found to inhibit cell growth in breast cancer cell lines, particularly in the basal subtype. MYC gene amplification was observed in 15.3% to 26% of breast cancer cases, with MYCMI-6 inducing apoptosis to decrease cell growth.

INVESTIGATIONAL NEW DRUGS (2021)

Review Cell Biology

The new role for an old guy: MYC as an immunoplayer

Dragan Marinkovic et al.

Summary: MYC, as an oncogene, not only controls cell growth and differentiation, but also plays a role in the formation of the tumor microenvironment, with increasing evidence suggesting its involvement in shaping the adaptive immune response, immunological memory development, and immunotolerance. This new understanding of MYC's role opens up new perspectives in biomedicine and potentially in the treatment of various pathological conditions.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Oncology

Recent insight into the role of FBXW7 as a tumor suppressor

Kanae Yumimoto et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Oncology

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype

Nicole M. Sodir et al.

CANCER DISCOVERY (2020)

Article Chemistry, Medicinal

Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Selena Chacon Simon et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Cell Biology

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc

Daniel Masso-Valles et al.

Editorial Material Oncology

The Myc and Ras Partnership in Cancer: Indistinguishable Alliance or Contextual Relationship?

Wadie D. Mahauad-Fernandez et al.

CANCER RESEARCH (2020)

Review Biochemistry & Molecular Biology

Human MYC G-quadruplex: From discovery to a cancer therapeutic target

Wenmeng Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Review Biochemistry & Molecular Biology

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

Sefan Asamitsu et al.

MOLECULES (2019)

Article Cell Biology

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

Marie-Eve Beaulieu et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Immunology

c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma

Kamini Singh et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene

Mark J. Demma et al.

MOLECULAR AND CELLULAR BIOLOGY (2019)

Article Multidisciplinary Sciences

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

Lance R. Thomas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Oncology

Antitumor efficacy of PARP inhibitors in homologous recombination deficient carcinomas

Tianjin Yi et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Article Biochemistry & Molecular Biology

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Yichen Xu et al.

NATURE MEDICINE (2019)

Review Hematology

The MYC oncogene is a global regulator of the immune response

Stephanie C. Casey et al.

Article Oncology

APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency

Cheng-Yu Tsai et al.

MOLECULAR CANCER THERAPEUTICS (2018)

Article Biochemistry & Molecular Biology

Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation

Stefano de Pretis et al.

GENOME RESEARCH (2017)

Article Biochemistry & Molecular Biology

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

L. C. Lustig et al.

ONCOGENE (2017)

Review Genetics & Heredity

MYC Deregulation in Primary Human Cancers

Manpreet Kalkat et al.

Review Cell Biology

Strategies to Inhibit Myc and Their Clinical Applicability

Jonathan R. Whitfield et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

Review Hematology

Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers

Markus Schick et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

Review Oncology

BET inhibitors: a novel epigenetic approach

D. B. Doroshow et al.

ANNALS OF ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells

Baojin Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

MYC regulates the antitumor immune response through CD47 and PD-L1

Stephanie C. Casey et al.

SCIENCE (2016)

Review Oncology

Oncogenic regulation of tumor metabolic reprogramming

Miriam Tarrado-Castellarnau et al.

ONCOTARGET (2016)

Review Biochemistry & Molecular Biology

Small-molecule inhibitors of the Myc oncoprotein

Steven Fletcher et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

Article Biochemistry & Molecular Biology

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

Yubao Wang et al.

Editorial Material Oncology

Targeting MYC Translation in Colorectal Cancer

Alina Castell et al.

CANCER DISCOVERY (2015)

Article Biochemistry & Molecular Biology

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Edmond Chipumuro et al.

Review Biochemistry & Molecular Biology

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

Junwei Shi et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

Inga Muller et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Inhibitor of MYC identified in a Krohnke pyridine library

Jonathan R. Hart et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, Research & Experimental

An Overview of MYC and Its Interactome

Maralice Conacci-Sorrell et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)

Article Cell Biology

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

Laura Soucek et al.

GENES & DEVELOPMENT (2013)

Article Multidisciplinary Sciences

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

Hanna Zirath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

MYC on the Path to Cancer

Chi V. Dang

Article Immunology

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

Dai Horiuchi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

Myc, Aurora Kinase A, and mutant p53R172H co-operate in a mouse model of metastatic skin carcinoma

E. C. Torchia et al.

ONCOGENE (2012)

Article Multidisciplinary Sciences

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins

William W. Lockwood et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E. Delmore et al.

Article Multidisciplinary Sciences

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber et al.

NATURE (2011)

Article Multidisciplinary Sciences

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers

Gregory S. Yochum et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

Dun Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Chemistry, Medicinal

Discovery of Novel Myc-Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

Gabriela Mustata et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function

Hao Jiang et al.

MOLECULAR PHARMACOLOGY (2009)

Article Oncology

Distinct Thresholds Govern Myc's Biological Output In Vivo

Daniel J. Murphy et al.

CANCER CELL (2008)

Article Biochemistry & Molecular Biology

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Ariele Viacava Follis et al.

CHEMISTRY & BIOLOGY (2008)

Article Multidisciplinary Sciences

Modelling Myc inhibition as a cancer therapy

Laura Soucek et al.

NATURE (2008)

Review Oncology

MYC - TIMELINE Reflecting on 25 years with MYC

Natalie Meyer et al.

NATURE REVIEWS CANCER (2008)

Article Oncology

Improved low molecular weight Myc-Max inhibitors

Huabo Wang et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Article Multidisciplinary Sciences

Non-transcriptional control of DNA replication by c-Myc

David Dominguez-Sola et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC

Andrei Goga et al.

NATURE MEDICINE (2007)

Article Biochemistry & Molecular Biology

Novel c-MYC target genes mediate differential effects on cell proliferation and migration

David Cappellen et al.

EMBO REPORTS (2007)

Article Multidisciplinary Sciences

Global mapping of c-Myc binding sites and target gene networks in human B cells

Karen I. Zeller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Oncology

The c-Myc target gene network

Chi V. Dang et al.

SEMINARS IN CANCER BIOLOGY (2006)

Article Biochemistry & Molecular Biology

A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, an G2 arrest

Victoria H. Cowling et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

A conserved element in Myc that negatively regulates its proapoptotic activity

A Herbst et al.

EMBO REPORTS (2005)

Article Biochemistry & Molecular Biology

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

M Yada et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

Low molecular weight inhibitors of Myc-Max interaction and function

XY Yin et al.

ONCOGENE (2003)

Article Multidisciplinary Sciences

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

ZR Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Cell Biology

Genomic targets of the human c-Myc protein

PC Fernandez et al.

GENES & DEVELOPMENT (2003)

Article Multidisciplinary Sciences

Direct activation of RNA polymerase III transcription by c-Myc

N Gomez-Roman et al.

NATURE (2003)

Article Multidisciplinary Sciences

Sustained loss of a neoplastic phenotype by brief inactivation of MYC

M Jain et al.

SCIENCE (2002)

Review Biochemistry & Molecular Biology

The Max network gone mad

TA Baudino et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)