期刊
CANCER SCIENCE
卷 112, 期 5, 页码 1924-1935出版社
WILEY
DOI: 10.1111/cas.14748
关键词
metachronous multiple primary lung cancer; non‐ small‐ cell lung cancer; registry; surgery; synchronous multiple primary lung cancer
类别
资金
- Japan Lung Cancer Society
- Japanese Association for Chest Surgery
- Japanese Respiratory Society
- Japan Society for Respiratory Endoscopy
- Japanese Association for Thoracic Surgery
The study investigated the clinical features and outcomes-related factors of MPLC patients using a Japanese database. It found differences between synchronous and metachronous MPLC patients in terms of gender, smoking status, lung function diseases, and histological types of lung cancer. This research provides valuable insights for MPLC diagnosis, prognosis, and postoperative management.
The number of patients with multiple primary lung cancers (MPLC) is rising. We studied the clinical features and factors related to outcomes of MPLC patients using the database of surgically resected lung cancer (LC) cases compiled by the Japanese Joint Committee of Lung Cancer Registry. From the 18 978 registered cases, 9689 patients with clinical stage I non-small-cell lung cancer who achieved complete resection were extracted. Tumors were defined as synchronous MPLC when multiple LC was simultaneously resected or treatment was carried out within 2 years after the initial surgery; metachronous MPLC was defined as second LC treated more than 2 years after the initial surgery. Of these cases, 579 (6.0%) were synchronous MPLC and 477 (5.0%) metachronous MPLC, with 51 overlapping cases. Female sex, nonsmoker, low consolidation-tumor ratio (CTR), and adenocarcinoma were significantly more frequent in the synchronous MPLC group, whereas patients with metachronous MPLC had higher frequencies of male sex, smoker, chronic obstructive pulmonary disease (COPD), and nonadenocarcinoma. There was no significant difference in survival rate between patients with and without synchronous or metachronous MPLC. Age, gender, CTR for second LC, and histological combination of primary and second LC were prognostic indicators for both types of MPLC. Logistic regression analysis showed that female sex, history of malignant disease other than LC, and COPD were risk factors for MPLC incidence. The present findings could have major implications regarding MPLC diagnosis and identification of independent prognostic factors, and provide valuable information for postoperative management of patients with MPLC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据